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Impact of a Ketogenic Weight loss plan versus a Mediterranean Weight loss plan on HbA1c in People with Prediabetes and Kind 2 Diabetes Mellitus: the Interventional Keto-Med Randomized Crossover Trial

Proper off the bat, I do not like that they studied each diabetes and prediabetics. There have been solely 40 authentic examine contributors, with full information on solely 33. Why lump the 2 collectively?

Members adopted every eating regimen for 12 weeks then lab information and physique weight had been assessed.

The researchers conclusions:

HbA1c [a measure of blood sugar control] was not totally different between eating regimen phases after 12-weeks, however improved from baseline on each diets, probably as a result of a number of shared dietary elements. WFKD [ketogenic diet] was useful for larger lower in triglycerides, but additionally had potential untoward dangers from elevated LDL-C, and decrease nutrient intakes from avoiding legumes, fruits, and complete intact grains, in addition to being much less sustainable.

Triglycerides dropped extra on the keto eating regimen, no shock. Physique weight dropped the identical for each diets, 7-8%. HDL-cholesterol (the “good ldl cholesterol”) rose 11% on keto and seven% on the Mediterranean eating regimen. HgbA1c dropped the identical on each diets, about 8% from baseline. Each diets result in consuming ~300 energy much less per day than baseline consumption.

Dr Bret Scher addressed the elevated LDL-cholesterol (aka “unhealthy ldl cholesterol”) over at

The authors reported that LDL “dangerously” rose 10% on the keto eating regimen. However was it actually a harmful change? Triglycerides went down on the keto eating regimen, as we might anticipate. And as we noticed in 2018 with the Virta Well being trial, on common, LDL went up 10%. Nonetheless, the calculated cardiac danger rating went down 12%.

By way of answering the headline query, Keto Versus Mediterranean Weight loss plan: Which Is Finest for T2 Diabetics and Prediabetics?, the reply actually depends upon long-term information regarding longevity and varied illnesses. This examine would not reply the query.

What say you?

Steve Parker, MD

front cover of Conquer Diabetes and Prediabetes